Endocrine Abstracts

In contrast to bone formation biomarkers, reliable bone resorption biomarkers have not been available in serum. Recently, automated measurement of C-terminal cross-linking telopeptide of type I collagen (CTX-I), has been promoted as a reliable indicator of bone resorption. The objective of the study was to examine the correlation of CTX-I, with the traditional urinary markers, N-telopeptide of type I collagen (NTX-I) and deoxypyridinoline (DPD) in a series of patients with Pag...

Aim: To evaluate the effect of PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, LIPC C(-514)T, ACE I/D, SLCO1B1 Val174Ala polymorphism on the response to statins therapy in patients with type 2 diabetes mellitus (T2DM).Methods: We consecutively recruited patients with type 2 DM requiring lipid-lowering therapy according to current guidelines. Patients were started on either atorvastatin 10 or 20 mg. After 12 month of st...

Background: Growth hormone (GH) deficiency causes visceral obesity and fatty liver and increases cardiovascular event risks. Because serum high-sensitivity C-reactive protein (hs-CRP) levels, which has been used to estimate those risks, was reported to be decreased by GH supplementation therapy in GH deficient patients, it has been suggested that inflammatory processes might be activated in GH deficient state. However, the clinical factors associated with increased hs-CRP leve...

Introduction: Full blood count (FBC), C-reactive protein (CRP), albumin and serum inflammation-based scores reflect systemic inflammation and predict outcomes in oncological patients. While these are increasingly used in cancer, little is known in pituitary adenomas (PAs). We aimed to characterise FBC and inflammation-based scores in patients with PAs and investigate the usefulness of such parameters in predicting aggressive/refractory disease.Methods: W...

Aim: To assess the association of the endothelial dysfunction (ED) parameters and the lipid-lowering response to atorvastatin therapy in patients with T2D with genetic markers of inflammation.Methods: We include 97 T2D patients with first prescribed atorvastatin 10–20 mg: M/F 26/71; mean age 57 years. After 12 month of statin therapy, patients had fasting lipid profiles and ED parameters repeated. For ED evaluation, we performed pulse wave analysis ...

Human thyroid follicular cells in culture synthesise plasminogen activators, both urokinase (uPA) and tissue-type (tPA). The PAs secreted into the culture medium were active (2.5–50 U/ml) and able to mediate the conversion of plasminogen to plasmin. Secreted PA activity (PAA) was markedly increased by epidermal growth factor (EGF) and protein kinase C (PKC) activation with TPA. There was a corresponding increase in uPA and tPA mRNA levels and in uPA and tPA protein secret...

Aims: To examine whether Graves’ disease (GD) and Hashimoto thyroiditis (HT) are associated with insulin resistance (IR) and other cardiovascular risk factors. Patients and methods: We analyzed 479 patients with autoimmune thyroid disease, 354 (74%) with HT and 126 (26%) with GD, 94% woman, with a mean age of 46±16 years. The patients in both groups were properly treated in order to normalize TSH, FT3 and FT4 levels. We recorded thyroid function...

Background: Serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are useful indicators of inflammation in patients with sub-acute thyroiditis. Despite the widespread use of several diagnostic tests, the purpose of this study was to compare the usefulness serum CRP and ESR in deciding which patient requires of glucocorticoid therapy.Methods: A total of 28 patients with sub-acute thyroiditis, included in this study. Serum CRP and ESR mea...

Background: Pheochromocytoma (PHEO) and paraganglioma (PGL) are the tumors of adrenal medulla and extra adrenal ganglia respectively. Most of these PHEO/PGL are benign and may become malignant, if remain undiagnosed/untreated for a longer time. Vaginal PGL are extremely rare. There is not much published literature on vaginal PGL.Objective: To carry out biochemical and genetic analysis of the patient with MIBG negative malignant vaginal PGL.<p class="...

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate is now 85% which emphasis the importance of long-term treatment complications. GH-deficiency (GHD) is common among these survivors treated with cranial radiotherapy (CRT) and chemotherapy. Renal impairment has been reported in childhood (CO) cancer survivors and glomerular filtration rate (GFR) is decreased in hypopituitarism. GH therapy to CO GHD patients has been show...